The protein of AGER, the receptor for advanced glycation end products (RAGE), contributes to both chronic inflammatory and tissue remodeling processes (Yan et al., 2010) in many refractory and chronic organ degenerative disease, such as Alzheimer’s disease (Galasko et al., 2014; Walker et al., 2015), Parkinson’s disease, diabetes (Soro-Paavonen et al., 2008), atherosclerosis (Bro et al., 2008; Harja et al., 2008) and chronic lung disease (Nicolls and Laubach, 2014; Oczypok et al., 2017). This evidence concerns the gene AGER and early-onset autosomal dominant Alzheimer disease.