In this respect, the most interesting targets that are involved in diabetic retinopathy and can bind curcumin were Toll-like 9 (Stewart et al., 2015; Jiang and Chen, 2017) receptor and Akt kinases (RAC serine/threonine protein kinase) (Jacot and Sherris, 2011). This evidence concerns the gene AKT1 and diabetic retinopathy.