Differential methylation patterns and decreased expression of DNA methyltransferase 3a are found in cerebellar neurons of a mouse model for presymptomatic Niemann-Pick type C disease (Kennedy et al., 2016) and Hubner et al. (2015) provide the only report on alteration of calcitonin receptor promotor methylation in FD patients on enzyme replacement therapy. Here, CALCR is linked to Niemann-Pick disease type C.