Csf1r, which was downregulated in our screen, facilitates protection and survival of uninjured neurons in the hippocampus and cortex (Luo et al., 2013), and Csf1r signaling via administration of Csf1 ameliorates memory deficits in an Alzheimer's disease mouse model (Boissonneault et al., 2009). Here, CSF1 is linked to early-onset autosomal dominant Alzheimer disease.