E2F3, a member of E2F family, is downregulated in the HCT 116 and RKO colon cancer cell lines.44 You et al45 determined that with the differential expression of dishevelled segment polarity protein 2 (DVL2), the Wnt signaling pathway may contribute to colon carcinogenesis. The gene discussed is DVL2; the disease is malignant colon neoplasm.