However, the spatial interaction between Macrophages PD-L1+ and cytotoxic T cells, epithelial cells and all T-cell lymphocytes, and between Macrophages PD-L1+ and cytotoxic T cells were identified by our models as the most important interactions in predicting the likelihood of a concurrent high-grade cyst in a patient with a low-grade cyst (9%, 7.5%, and 5% decrease in accuracy, respectively). This evidence concerns the gene CD274 and cyst.