CD274 and pancreatic intraductal papillary-mucinous neoplasm: The finding that the spatial distribution of both Macrophages PD-L1+ and all macrophages with respect to cytotoxic T-cell lymphocytes in low-grade IPMN can predict the presence of simultaneous low- and high-grade dysplasia, which indicates that macrophages may suppress cytotoxic T-cell activity early in the development of PDAC.