KCNN2 and amyotrophic lateral sclerosis: To determine the impact of SK2 channel activity on ALS-associated defects in this model, we re-created the V698F (equivalent to SK2-a V407F) mutation in the orthologous C. elegans gene, kcnl-2 (Fig. 6a), using CRISPR/Cas9-mediated homologous recombination-based genome editing.