GLP1R and Parkinson disease: To our knowledge, there are currently no literature reports of GLP-1R agonists in α-synuclein rodent models of PD; however, the promising activity of Exendin-4 (administered by s.c. pump to maintain long-term steady-state levels) in a murine model of multiple system atrophy that involves the development of an α-synuclein load in the striatum51, suggests that the evaluation of long-term administration of Exendin-4 in PD α-synuclein models may represent a promising avenue.