There is currently increasing interest in the value of GLP-1 receptor agonists as a neuroprotective treatment strategy for neurodegenerative disorders, and particularly for PD in the light of recent clinical trials with the T2DM approved drug, Exendin-435, as well as ongoing and planned clinical safety/efficacy studies with liraglutide (NCT02953665) and lixisenatide. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.