Bap1 depletion resulted in a profound reduction in the numbers and sizes of cSAM cell colonies (Fig. 7f and Supplementary Fig. 7a), and also delayed the development of leukemia in mice, suggesting an important role for Bap1 in ASXL1-MT-induced leukaemogenesis (Fig. 7g). The gene discussed is ASXL1; the disease is leukemia.