A variety of animal models have produced limited phenotypic resemblances with schizophrenia and its comorbidities, as in the case of Disc-1, Nrg1, and ErbB4 knockouts; and in some instances included also phenotypic divergences, as in the case of unimpaired hippocampal-dependent memory and lack of social-interaction reduction in amphetamine models, lack of sustained PPI deficit in phencyclidine models, increased PPI in dysbindin knockout, and reduced locomotion in reelin knockout60. The gene discussed is RELN; the disease is schizophrenia.