On the other hand, when 40 polymorphisms in 12 ‘top’ candidate genes for schizophrenia including AKT1, COMT, DAO, DRD2, DRD4, DTNBP1, GABRB2, IL1B, MTHFR, PPP3CC, SLC6A4, and TP53 with familial association data were subjected to meta-analysis, only the disease association of rs1816072 upstream of AluYi6AH-151 in GABRB2 remained significant after correction for multiple testing20. The gene discussed is DTNBP1; the disease is schizophrenia.