Consequently, a deeper understanding of how different neurotransmitter and neuronal systems interact in schizophrenia to generate its symptoms and comorbidities, obtained through integrated approaches including clinical and genetic studies, investigation of postmortem schizophrenic brains and thorough analysis of the Gabrb2-knockout model, will be important for not only delineation of the complex etiology of schizophrenia, but also expedited searches for improved drugs to treat the disease. This evidence concerns the gene GABRB2 and schizophrenia.