TMEM106B and neoplasm: We observed that in each of the different human and murine tumor cell models, upon TMEM106B induction, the enlarged lysosomes are loaded with active cathepsin B as evident from the enhanced red fluorescence in the lysosomal vesicles (Fig. 4a–c and Supplementary Figure 3D) and significant increase in florescence intensity (Fig. 4d and Supplementary Figure 3E).