We observed that in each of the different human and murine tumor cell models, upon TMEM106B induction, the enlarged lysosomes are loaded with active cathepsin B as evident from the enhanced red fluorescence in the lysosomal vesicles (Fig. 4a–c and Supplementary Figure 3D) and significant increase in florescence intensity (Fig. 4d and Supplementary Figure 3E). The gene discussed is CTSB; the disease is neoplasm.