MYC and neoplasm: Similarly, analysis of the HBEC-iKRASG12D;GATAD2B tumor protein lysates by Reverse Phase Proteomics Array (RPPA) compared to small, arrested GFP tumors showed elevated protein levels consistent with three previously published reports of MYC target pathway activation confirmed by chromatin immunoprecipitation49, ChIP on chip of cell lines identifying high-affinity MYC-binding50, or identified from the Pathway Interaction Database51 (Supplementary Table 3, Supplementary Fig. 7, Fig. 5e).