Notably, although a hyper Th17 response (elevated IL-17) was also observed in Il17ra−/− and Il17rc−/− mice, SLE- and Sjögren’s-like diseases were not observed in these mice, indicating that the autoimmune phenotype in Act1−/− mice is probably not simply due to lack of IL-17 signaling. Here, IL17RC is linked to systemic lupus erythematosus.