Importantly, TRAF3IP2 (coding for Act1) polymorphisms [rs33980500 (Act1-D10N) and rs13193677] were reported to have significant association with SLE susceptibility (p = 0.021, odds ratio (OR) = 1.71, and p = 0.046, OR = 1.73, respectively). Here, TRAF3IP2 is linked to systemic lupus erythematosus.