CRP and obesity due to melanocortin 4 receptor deficiency: Univariate linear regression analysis indicated that race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, HbA1C, high-density lipoprotein, triglyceride, vitamin D, and CRP were significantly associated with HOMA-IR (Supplement Table 1).