In addition, the administration of triptolide (a diterpenoid isolated from Tripterygium wilfordii Hook F), having immunosuppressive and anti-tumor activities, decreased the expressions of FXR and the silent information regulator 1 (SIRT1) (a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase regulating FXR activity [35]) in the liver of rats [36]. This evidence concerns the gene NR1H4 and neoplasm.