NR1H4 and serum lipopolysaccharide activity: It has been suggested that FXR involves in the regulation of cholestasis-associated sepsis, which can be mediated by the negative regulation of NACHT, leucin-rich-repeat (LRR), and pyrin (PYD) domains-containing protein 3 (NLRP3) inflammasome via the direct binding of FXR to NLRP3 and caspase 1 in macrophages [81,82]; thus, the FXR deficiency sensitized the mice to endotoxemia shock.