In mice fed a methionine and choline-deficient (MCD) diet, as a murine model of nonalcoholic steatohepatitis (NASH), the FXR agonist WAY-362450 (also known as FXR-450) lessened the hepatic inflammation and fibrosis development [38]. This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatohepatitis.