ACE and hepatocellular carcinoma: To assess the effects of MKH-ester prodrugs on HCC cell proliferation, DCP-positive (PLC/PRF/5) and DCP-negative (SK-Hep-1) HCC cell lines were treated with various concentrations of MKH-ACT, MKH-DMG, MKH-SUC or MK-4 up to 96 h, and cell viability was determined.