Also, whereas heterozygosity for the frameshift/premature stop codon mutation [A553ΔAAAiT]fs.185[stop186] in the DNA-binding domain of PPARγ is not associated with insulin resistance, individuals doubly heterozygous, with an additional defect in an unrelated gene encoding the muscle-specific regulatory subunit of protein phosphatase 1 (PPP1R3A), exhibit severe insulin resistance [50]. This evidence concerns the gene PPP1R3A and Insulin resistance.