Other established biomarkers for endothelial function are asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule 1 (sVCAM-1), interleukin-6 (IL-6), von Willebrand Factor (vWF), and soluble intercellular cell adhesion molecule 1 (sICAM-1), all of which have been related to renal endothelial health and vascular complications in T2D [7]. The gene discussed is VWF; the disease is type 2 diabetes mellitus.