In addition to endothelial dysfunction, a number of metabolic disorders are associated with microalbuminuria leading to cardiovascular damage: transvascular leaking of albumin in vessels, elevated glomerular filtration rate, elevated blood pressure, hyperinsulinemia, elevated plasma fibrinogen levels, and altered blood lipid levels and function may also play important roles [31, 32]. The gene discussed is ALB; the disease is hyperinsulinism.