Even though not accountable for the CXCL12 scoring, we also found positive CXCL12 expression in tumor-associated macrophages and cancer-associated fibroblasts, in accordance with previous studies where CXCL12 is mainly secreted by tumor cells, but also by stromal cells, including tumor-associated macrophages and cancer-associated fibroblasts [7, 29]. The gene discussed is CXCL12; the disease is cancer.