Unlike colon surveillance, current guidelines for upper GI surveillance do not distinguish between APC genotype; baseline upper endoscopy with side viewing is recommended starting at age 20 to 25 with a frequency ranging from 3 to 48 months as determined by the extent of duodenal polyposis (NCCN Guidelines Version 2.2015) [9]. The gene discussed is APC; the disease is Duodenal polyposis.