TP53 and neoplasm: The subnetworks significantly enrich for the KEGG pathways of cell cycle (FDR = 2.03 × 10− 9), P53 signaling (FDR = 4.10 × 10− 5), NOTCH signaling (FDR = 0.00163) and many other tumor related pathways (Additional file 7: Table S5a).