The association of HK with VDAC1 offers numerous benefits to cancer cells [69]: (a) production and access to energy and metabolites [21,70]; (b) VDAC1-HK complex acts as an anti-apoptotic protein, preventing cytochrome c release and following apoptosis [24,71,72,73,74,75,76,77]. The gene discussed is HK1; the disease is cancer.