VDAC has been also proposed as a target for fluoxetine (Prozac) able to decrease channel conductance by inhibiting the opening of the mitochondrial permeability transition pore (mPTP), the release of cytochrome c and the proliferation of several cancer cells lines (i.e., hepatocellular carcinoma cells) [46,47,48,49,50,51,52]. This evidence concerns the gene CYCS and cancer.