HK2 and melanoma: The list of these compounds includes agents that can disassociate this binding, such as HKI- and HKII-derived peptides [81], synthetic VDAC1-based peptides [72,74,77], clotrimazole, that at high concentrations (20 μM) dissociates HK-II from mitochondria in melanoma cells, [74,76,82,83], a cell-permeable HKII-based peptide [78], and methyl jasmonate causes the inhibition of glycolysis and the induction of mitochondrial outer membrane permeabilization.