CYCS and cancer: In this class, we found avicins, compounds that targeted and closed VDAC in lipid bilayers, triggering OMM permeabilization and release of cytochrome c [33,34], aspirin that binds and modulates directly the membrane-reconstituted VDAC, inducing an anticancer effect in various cancer cell lines (i.e., colon cancer, chronic lymphocytic leukemia, and myeloid leukemia) [35].