Kv1.5 was instead overexpressed in osteosarcoma and its silencing could suppress osteosarcoma progression inducing cell cycle arrest at G0/G1 phase, and apoptosis through up-regulation of p21, p27, Bax, Bcl-XL, and caspase-3 and down-regulation of cyclins A, cyclins D1, cyclins E, Bcl-2, and Bik [222]. This evidence concerns the gene CASP3 and osteosarcoma.