AKT1 and cancer: They also showed that blocking autophagy (1) attenuated GGCT depletion-mediated CDKI upregulation and cell cycle arrest; (2) rescued cell growth inhibition caused by GGCT knockdown; and (3) inhibited cellular senescence induced by GGCT knockdown; in addition, they found that GGCT depletion activated the AMPK-ULK1 pathway and led to the inactivation of the mTORC2-AKT pathway in cancer cells.