ANGPTL3 and atherosclerosis: Conversely to the FLDs from other angiopoietins that bind to endothelial cells via Tie receptors (Tie1 and Tie2) [72], ANGPTL3’s FLD binds to integrin αVβ3 [31]; while this interaction has a proven role in the case of renal damage [33,34,35], a more puzzling scenario is depicted for its importance in atherosclerosis.