From experimental evidence, it was then observed that individuals with loss-of-function (LOF) mutations (Table 1) in the ANGPTL3 gene were affected by familial combined hypolipidemia (FHBL2) and characterized by very low levels of apolipoprotein B (apoB), apolipoprotein A1 (apoA-1) and their associated lipoproteins -very low-density lipoprotein (VLDL), LDL and HDL respectively compared to non-carriers [7,8,9]. Here, APOA1 is linked to familial hypobetalipoproteinemia 2.