Similarly, signaling of CREB-autonomous cells is critically involved in regulating survival, migration, and morphological differentiation of cough neuroblastomas in adult SVZ, but loss of CREB induces an increase in the signal for Pax6 expression, suggesting that the effects of CREB signaling on the survival of immature neurons in RMS may be mediated by Pax6 modulation [48]. The gene discussed is CREB1; the disease is neuroblastoma.