These genes are involved in DNA repair: PUMA is a p53 upregulated modulator of apoptosis; P21 a regulator of cell cycle progression at G1; ZMAT3 encodes a protein containing three zinc-finger domains and over expression of this gene inhibits tumor cell growth; SESN1 plays a role in the cellular response to DNA damage and oxidative stress-induced over expression inhibits tumor cell growth, and the expression of this gene is a potential marker for exposure to radiation; and CCNG1 encodes a human homologue of the rat G-type cyclin. The gene discussed is ZMAT3; the disease is neoplasm.