COMT and coronary artery disorder: Our findings showed that COMT rs4680 G > A polymorphism is associated with an increased risk of coronary artery disease for COMT-GA vs. GG genotype (OR = 3.5, 95% CI 1.58–7.74; RR 1.62, 95% CI 1.25–2.10; p = 0.0002) in the codominant inheritance model.