Increased levels of APRIL, a bona fide member of the TNF ligand superfamily, were previously demonstrated in the serum of patients with pancreatic cancer and were shown to correlate with early tumor recurrence and an impaired patients’ prognosis [15,16,17], suggesting that other members of the TNF superfamily might hold a similar role. Here, TNFSF13 is linked to familial pancreatic carcinoma.