A prospective cohort study including data from 46 200 individuals from the Copenhagen General Population Study showed that for patients with familial hypercholesterolemia (FH), the highest risk of CVD was associated with Lp(a) values ≥ 50 mg/dL (HR 5.3, 95% CI 3.6–7.6), and CVD risk remained high with normal Lp(a) values (HR 3.2, 95% CI 2.5–4.1) when compared with the reference group of subjects without FH and Lp(a) values ≤ 50 mg/dL.6 Here, LPA is linked to familial hypercholesterolemia.