Such murine models include spontaneous models such as spontaneously hypertensive rats (SHR)1, streptozotocin (STZ)-induced diabetic rats and mice2, and the db/db type II diabetic mice3, genetically engineered models such as primary podocyte-specific focal segmental glomerular sclerosis (FSGS) models4, the podocyte-specific vascular endothelial growth factor A (VEGF-A) knock-out (VEGF-A KO) model5, and Alport syndrome models6, and acquired models such as the 5/6 nephrectomy7 and the unilateral ureteral obstruction (UUO) model8. Here, VEGFA is linked to focal segmental glomerulosclerosis.