HIF1A and neoplasm: The overexpression of CUX1 in pancreatic neuroendocrine neoplasm cells upregulates hypoxia inducible factor‐1α (HIF‐1α) and matrix metalloprotein 9 (MMP9), and the paracrine stimulation of endothelial cells then leads to tumour angiogenesis.15 However, the biochemical role of CUX1 in vascular endothelial cells renains unclear.