The overexpression of CUX1 in pancreatic neuroendocrine neoplasm cells upregulates hypoxia inducible factor‐1α (HIF‐1α) and matrix metalloprotein 9 (MMP9), and the paracrine stimulation of endothelial cells then leads to tumour angiogenesis.15 However, the biochemical role of CUX1 in vascular endothelial cells renains unclear. This evidence concerns the gene HIF1A and pancreatic neuroendocrine neoplasm.