As a routine test, we measured the serum levels of seven conventional cancer biomarkers, including carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA 19-9), carbohydrate antigen 15-3 (CA15-3), carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE), and cytokeratin 19 fragment (CYFRA21-1). The gene discussed is ENO2; the disease is cancer.