SPP1 and metabolic dysfunction-associated steatohepatitis: 2004). Treatment with curcumin significantly lowered hepatic SPP1 mRNA expression possibly further attenuating inflammation. While no differences in fibrosis were observed in either group, key fibrotic inflammatory signals such as TNFα and Col1a1 mRNA were lowered with curcumin supplementation. These well‐established profibrotic markers have been implicated in the progression of NASH and fibrosis development (Palacios et al. 2008; Braunersreuther et al. 2012).