INS and obesity due to melanocortin 4 receptor deficiency: So, despite our obese participants displaying some of the classical hallmarks of the metabolic syndrome (i.e., elevated fasting insulin, increased insulin resistance, and dyslipidemia), in addition to increased systemic concentrations of the inflammatory mediator CRP, it is possible that being young and physically active may have mediated some protection against obesity‐related anabolic resistance (to exercise or nutrition).