Obesity was associated with higher basal levels of serum insulin (P < 0.05), plasma triacylglycerol (P < 0.01), plasma cholesterol (P < 0.01), and plasma CRP (P < 0.01), as well as increased insulin resistance determined by HOMA‐IR (P < 0.05). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.