Coordination between MMP‐1 and CXCR4 or stromal‐derived factor‐1 signaling influences the behavior of activated fibroblasts in autoimmune diseases and cancers.85, 86, 87, 88 In addition, MMP‐1 is a vital part of an autocrine‐paracrine MMP‐1‐PAR‐1 signal transduction axis—a role that amplifies the potential of MMP‐1 to remodel the matrix and modify cell behavior.87, 88 Finally, new therapeutic agents directed at MMP‐1 and G protein‐coupled receptors might be emerging. The gene discussed is CXCR4; the disease is autoimmune disease.