Our research group has previously demonstrated that S100A10 (p11) is a receptor for the pro‐protease plasminogen and can drive cancer cell invasion by mediating the conversion of plasminogen into the active protease, plasmin (Choi et al., 2003; Zhang et al., 2004; Phipps et al., 2011; Kwon et al., 2005; O'Connell et al., 2011; Madureira et al., 2012; Bydoun and Waisman, 2014). The gene discussed is S100A10; the disease is cancer.