Calculation of the ratio of Th2 (IL-13 and IL-5)/Th1 (IFN-γ and TNF-α) cytokines at 180 days for the best responders in both groups (n = 2 in LN and n = 1 in SC) revealed that Th2 response was three times stronger in LN patients than in the SC group (ratio: 6.44 LN versus 2.24 SC). Here, TNF is linked to lobular neoplasia.