Since the number of cases and controls included in the current meta-analysis is relative huge, our results would be relatively reliable, and we could conclude that HLA-DP gene polymorphisms (DPB1∗03:01, DPB1∗04:02, DPB1∗13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer, which would be regarded as early warning factors. This evidence concerns the gene HLA-DPA1 and cervical carcinoma.