RTN4 and cancer: We performed functional gene set enrichment analysis on genes containing DMS using the DAVID web server and found that many of the 47 differentially methylated genes are related to important biological functions of cancer, for example, regulation of apoptosis and programmed cell death with RTN4, NME2, CASP14, HSPB1, RPL11, and RPS3 differentially methylated (Excel Sheet S1).