Interestingly, the mouse genome exhibits a similar gene architecture around Pten, with at least the presence of Atad1, Rnls, Papss2, and Minpp1. The prostate-specific loss of Pten PCa mouse model (Ptenflox/flox;PB-Cre4+) is one of the most commonly used in vivo models to study PCa development and progression (5, 48). Here, RNLS is linked to posterior cortical atrophy.