PTEN and cancer: Again, the same similar minimal region seems to accompany the loss of PTEN, altering the same set of genes as in the more aggressive SU2C cohort, including the deletion breakpoint in the intronic region of RNLS. These results suggest that the loss of 10q23 in PCa cells does not solely inactivate the tumor suppressor PTEN, but that there is also a selective pressure to lose other gene(s) at this particular genomic region in this specific type of cancer.