PTEN and cancer: However, other genes located in the minimal deleted region at 10q23 might play a significant role in PCa etiology because (1) CNA is the major genomic alteration in PCa, not a direct mutation of PTEN, which occurs in all other types of cancer; (2) a large region at 10q23 is deleted, comprising more than just PTEN and often including the loss of at least six other genes; and (3) some of these genes have already been associated with tumor suppressing functions in PCa or other cancers.