PTEN and posterior cortical atrophy: We further analyzed the PTEN genomic alteration status between the different PCa cohorts (Figure 2A), which included the Michigan, Stand Up To Cancer (SU2C), and Fred Hutchinson Cancer Research Center datasets, mostly comprising metastatic samples (12, 13, 22); the Trento/Cornell/Broad dataset, composed of metastatic neuroendocrine prostate cancer (23); the Broad/Cornell 2012, Broad/Cornell 2013, Memorial Sloan Kettering Cancer Center, and the two TCGA datasets, comprising mostly primary localized PCa (9, 11, 16, 24).