These wild-type PCa cell lines thus represent potential in vitro models to study the impact on PCa cell proliferation of PTEN inactivation, with and without inactivation of one or more of the other genes located within the minimal deleted region at 10q23 (KLLN, ATAD1, RNLS, PAPSS2, MINPP1, and CFLIP1). The gene discussed is PAPSS2; the disease is posterior cortical atrophy.