The most common form of dementia is AD, which is characterized by brain pathology consisting of extracellular Aβ plaques, intraneuronal tangles of phosphorylated tau protein, synapse loss, and neuronal loss (Hardy, 2002; Kerbler et al., 2015).The transition from mild cognitive impairment (MCI) to AD can be monitored in PET studies with amyloid-beta (Aβ) ligands such as [11C]-PiB and [18F]-AV45 (Florbetapir) (Nemmi et al., 2014; Saint-Aubert et al., 2013). This evidence concerns the gene MAPT and Alzheimer disease.