We investigated if p62 signaling plays a role in MM cell upregulation of GFI1 expression and induces GFI1-mediated epigenetic repression of Runx2. Direct co-culture (48 h) of murine 5TGM1 MM with murine preOB MC4 cells in proliferation media suppressed Runx2 mRNA (Figure 1A, d0). This evidence concerns the gene GFI1 and Miyoshi myopathy.