HTT and Huntington disease: We have previously designed a new iPSCs-based model of HD, and experiments with it have shown that SOCE in HD-specific GABA MSNs (HD GABA MSNs) is pathologically enhanced, compared to wild-type GABA MSNs (WT GABA MSNs), and that this enhancement is closely correlated with the expression of mutant huntingtin in the cells (Nekrasov et al., 2016).