Moreover, Gal-3 has been identified in central as well as peripheral nervous system in Schwann cells, endothelial cells, microglia/macrophages, and astrocytes; and the activation of endothelial cells and microglia has been intricately associated with AD pathogenesis (Zlokovic, 2008; Ottum et al., 2015). The gene discussed is LGALS3; the disease is Alzheimer disease.