These findings indicate that B7-H4 expression might be linked to more aggressive subtypes of breast cancer and are consistent with previous studies reporting that B7-H4 expression is associated with a poor prognosis in oral squamous cell carcinoma [41], non-small cell lung cancer [42], renal cell carcinoma [43], and glioma [44]. This evidence concerns the gene VTCN1 and hereditary clear cell renal cell carcinoma.