Chromosomal deletions have also been found in CIN, in genomic regions containing FHIT (Fragile histidine triad), WWOX (WW domain containing oxidoreductase), STK3 (Serine/threonine kinase 3), CDH1, CTNNA1 (Catenin alpha 1), PARD3 (Par-3 family cell polarity regulator), and RB1 (retinoblastoma 1) [64]. The gene discussed is RB1; the disease is cervical squamous intraepithelial neoplasia.