When applied to both ACRG and TCGA data sets, they observed similarities among MSI tumors in both data sets, and they showed that the TCGA GS, EBV+ and CIN subtypes were enriched in ACRG MSS/EMT, MSS/TP53+ and MSS/TP53− subtypes, respectively. This evidence concerns the gene TP53 and cervical squamous intraepithelial neoplasia.