TP53 and cancer: Asian Cancer Research Group gene expression signatures defined four molecular subtypes of GC, which were different from the TCGA subtypes: MSI (N = 68), epithelial-to-mesenchymal transition (microsatellite stable (MSS)/EMT, N = 46), MSS/TP53 positive (N = 79) and MSS/TP53 negative (N = 107).