The ongoing phase III KEYNOTE-062 is testing pembrolizumab as a monotherapy and in combination with chemotherapy in the first-line treatment of PD-L1–positive advanced GC or GEJ cancer, while the phase III KEYNOTE-585 is evaluating the combination of pembrolizumab with chemotherapy in the neoadjuvant and adjuvant settings. This evidence concerns the gene CD274 and gastric cancer.