Using four relatively sensitive T-ALL cell lines based on IC50 values—HPB-ALL, Loucy, MOLT-3, and RPMI-8402—we demonstrated the induction of significant apoptosis by annexin V/propidium iodide (PI) staining after 24 h of treatment with S63845 (Supplementary Figure 3a, b). This evidence concerns the gene ANXA5 and acute lymphoblastic leukemia.