The anti-apoptotic BCL-2 family proteins BCL-2, BCL-XL, and MCL1 can each bind and sequester BH3-only pro-apoptotic proteins, such as BIM, BID, and PUMA [2, 13], raising the possibility that two very specific inhibitors such as venetoclax (BCL-2) and S63845 (MCL1) might act synergistically to kill T-ALL cells. The gene discussed is BCL2L1; the disease is acute lymphoblastic leukemia.