SOX9 and cancer: Moreover, SOX9 as well as mTORC1, is associated with tumorigenesis in several cancers (Grabiner et al., 2014, Jo et al., 2014, Pritchett et al., 2011, Sato et al., 2010), identifying the mTORC1/4E-BPs/SOX9 cascade as a prominent candidate for developing drugs targeting various human diseases.