DISC1 and schizophrenia: 2006; Hayashi‐Takagi et al. 2010; Carlisle et al. 2011). Curiously, synaptic transmission per se appears to be largely intact in most DISC1 mutants (Cui et al. 2016), although in some cases it may adopt a less mature form than normal (Greenhill et al. 2015). Instead, the main effect of DISC1 on synaptic function appears to be its effect on synaptic plasticity. Synaptic plasticity is often studied in animal models of schizophrenia by measuring LTP, and it is therefore highly pertinent that LTP has been found to be deficient in schizophrenia patients (Frantseva et al. 2008).