CD4 and AIDS: Undoubtedly, patients infected with HIV suffer from chronic and persistent inflammatory processes, which cause numerous AIDS and non-AIDS-related complications such as neurocognitive deterioration, cardiovascular disease, thromboembolic disease, type II diabetes, cancer, osteoporosis, multiple end-organ disease, and frailty (Deeks et al. 2013; Barré-Sinoussi et al. 2013; Hearps et al. 2014), even when patients adhere to cART regimens that minimize viral replication and increase CD4 cell counts (Appay and Sauce 2008; Funderburg et al. 2014).