Our data indicated that statin use, TG, duration of diabetes, c-IMT and ANGPTL8 in type 2 diabetic patients with subclinical atherosclerosis had a significant increase than in control subjects with NGT and type 2 diabetic patients without subclinical atherosclerosis, whereas leisure-time physical activity had a significant decrease in type 2 diabetic patients with subclinical atherosclerosis than in control subjects. Here, ANGPTL8 is linked to diabetes mellitus.