As shown by partial correlation analysis (Table 2 and Fig. 1), serum levels of ANGPTL8 were positively and significantly correlated with TG, duration of diabetes and c-IMT in type 2 diabetic patients with and without subclinical atherosclerosis groups (all P < 0.05) after adjustment for age, sex and BMI. This evidence concerns the gene ANGPTL8 and diabetes mellitus.